研究方向：情绪和学习记忆的神经机制研究和临床应用
电子邮箱：xiaoxiao@fudan.edu.cn
个人网站：https://faculty.fudan.edu.cn/xxiao/zh_CN/index.htm
简要介绍：
肖晓博士，复旦大学认知神经科学中心执行主任/研究员，复旦大学附属华山医院和华东医院双聘研究员，博士生导师。长江学者青年项目（2025），上海市东方英才（2023），上海科技启明星（2019），上海市神经科学学会疼痛转化研究分会副主任，Brain Communications（Q1）、Behavioural Brain Research （Q2）、Journal of Psychopharmacology（Q2）杂志副主编。
研究专长为使用神经生物学、认知心理学和计算科学等交叉前沿技术，围绕“情感的中枢机制及可塑性调控”这一科学主题，系统研究了情绪和情感记忆的神经生理和心理机制，推动了情感障碍中枢机制研究的发展及临床诊疗应用，并建立了一系列神经调控和行为疗法为基础的创新技术。研究成果以通讯或第一作者发表在Science，Molecular Psychiatry, Advanced Science（2025a,2025b,2024）, Cell Reports Medicine, Cell Reports（2018,2019）等杂志。著有中文科普著作《探索脑的奥秘》，翻译英文译著5本，其中神经外科医生Oliver Sacks著作《最初的爱，最后的故事》，获豆瓣年度榜单Top10推荐，《心灵奇景：80幅画描述意识之谜》获文津奖提名。于2025年获评为上海市大众科学传播新锐人物。以第一发明人获批专利8项。
代表成果：
1. Dissociation of spatial and contextual memory encoding under fear and pain in mice. Yichen Cai, Zheping Cai, Ruiqing Hou, Yuanfeng Weng, TrevorW. Robbins, Nan Chen#, Xiao Xiao#, Behavioural Brain Research, 507, 116203
2. From chronic pain to depression: Neurogenesis-driven microglial remodeling in the hippocampal dentate gyrus. Ming Ding*, Shitong Xiang*, Yuqing Zhang, Lei Wei, Yuanfeng Weng, Xueting Zhang, Yiling Ni, Yuwen Zhang, Qianfeng Wang, Ruiqing Hou, Huaihao Du, Jiaqi Zhao, Wei Zhang, He Wang, Tianye Jia, Yi Wu, Jianfeng Feng#, Trevor W. Robbins#, Xiao Xiao#, Science (2026), 391, eaee6177.
3. Downregulation of Integrin α3 in ADHD mirrored in mutant mouse model by dopamine-dependent hippocampal AMPAR expression. Xiaojuan Yao*, Ruiying Chen*, Jingxiang Zhu*, Ruiqing Hou, Shitong Xiang, Tianye Jia, Yuelin Gu, Zhenyv Wang, Han Hu, Hongting Chen, He Wang, Jianfeng Feng, Trevor Robbins, Yingwei Wang#, Michael Higley, Antony Koleske, Xiao Xiao#, Molecular Psychiatry (2025), 1-19
4. Cracking the Valence Code: Patterned Facial Kinematics and Neural Signatures of Emotional Expressions in Mice. Yujia Chen, Ruiqing Hou, Zhinan Chen, Junli Lu, Si Chen, Shisheng Xiong, Jianfeng Feng, Trevor W. Robbins, Haitao Yan, Xiao Xiao#, Advanced Science (2025), 12 (42), e17156
5. Ultrabright Ratiometric Raman-guided Epilepsy Surgery by Intraoperatively Visualizing Proinflammatory Microglia. Cong Wang, Zhi Li, Xiao Zhu, Yiqing Jiang, Wenjia Duan, Wanbing Sun, Ming Chen, Jiayi Hu, Zeping Cai, Xingyu Zhou, Xiao Xiao#, Liang Chen#, Cong Li# and Ying Mao#, Cell Reports Medicine (2025), 6 (6), 102155
6. Disentangling distinct neural circuits for emotional evaluation and uncertainty in the human amygdala underlying different mental disorders. Shitong Xiang, Chao Xie, Xiao Xiao, Wei Cheng, Tobias Banaschewski, Gareth J. Barker, Gunter Schumann, Benjamin Becker, Trevor W. Robbins#, Tianye Jia#, Jianfeng Feng#, IMAGEN Consortium and Stratify Consortium. Science Bulletin, (2025), S2095-9273(25)00188-4. doi: 10.1016/j.scib.2025.02.026.
7. Large-scale plasma proteomics to profile pathways and prognosis of chronic pain. Zeyu Li*, Qing Ma*, Jie Zhang*, Qizheng Hao*, Jia You, Xinrui Wu, Jujiao Kang, Linbo Wang, Yueting Deng, Yuzhu Li, Chun Shen, Bangsheng Wu, Jianfeng Feng, Yiheng Tu, Xiao Xiao#, Jintai Yu#, Wei Cheng#, Advanced Science, (2025), 12 (16), 2410160
8. Effects of intermittent theta burst stimulation on the inflammatory response and cerebral blood flow in promoting neurovascular repair after ischemic stroke. Jingjun Zhang, Siyue Li, Dan Huang, Jiale Fu, Shuying Chen, Na Ren, Pengkun Yang, Di Song, Xiaochen Bai, Hongyu Xie, Gang Liu, Kewei Yu, Shamay SM Ng, Junfa Wu, Xiao Xiao#, Yi Wu#, Molecular Brain (2025), 18 (1), 1-13
9. Regional and whole-brain neurofunctional alterations during pain empathic processing of physical but not affective pain in migraine patients. Dan Liu, Menghan Li, Heng Jiang, Yiqi Mi, Xiaolei Xu, Yali Zhou, Yaxian Hou, Yuquan Shen, Michael Maes, Xiao Xiao, Feng Zhou, Luca Giani, Keith M Kendrick, Benjamin Becker, Stefania Ferraro. The Journal of Headache and Pain (2025), 26(1),1-18
10. Intermittent theta-burst stimulation modulates glial cells via PI3K/AKT to improve the neurovascular unit in stroke mice. Jingjun Zhan*, Ming Ding*, Lu Luo, Dan Huang, Siyue Li, Shuying Chen, Yunhui Fan, Li Liu, Hongyu Xie, Gang Liu, Kewei Yu, Junfa Wu, Xiao Xiao#, Yi Wu#, Neural Regeneration Research, (2025), 21(0), 10.4103/NRR.NRR-D-24-01189
11. Effects of electroacupuncture per-conditioning at Huantiao on motor function recovery in acute cerebral ischemia mice. Jia-le Fu, Jing-Jun Zhang, Yi Wu, Nian-hong Wang, Qi Qi, Guo-hui Yang, Na Ren, Dan Huang, Yun Li, Li-juan Zhao, Xiao Cui#, Xiao Xiao#, Hong-yu Xie#, Physiology & Behavior, (2025), 292, 114814
12. Intermittent vibration induces sleep via an allatostatin A-GABAsignaling pathway and ameliorates memory impairment in Alzheimer's disease models. Yang Mou, Yan Zhang, Yuxian Zheng, Guang He, Zhi-Xiang Xu, Xiao Xiao#, Yong Ping#, Advanced Science, (2024), 12 (5), https://doi.org/10.1002/advs.202411768
13. Coordinated interactions between the hippocampus and retrosplenial cortex in spatial memory. Ruiqing Hou, Ziyue Liu, Zichen Jin, Dongxue Huang, Yue Hu, Wenjie Du, Danyi Zhu, Leiting Yang, Yuanfeng Weng, Tifei Yuan, Yingwei Wang, Bin Lu, Yong Ping#, Xiao Xiao#, Research, (2024), Volume 7, 0521
14. Differential efficacy of modified enriched environment on motor, emotion, and cognition in cortical ischemic mice. Dan Huang, Yunhui Fan, Jingjun Zhang, Yuanfeng Weng, Xiao Xiao#, Yi Wu#, Junfa Wu#, Cerebral Cortex, Volume 34, Issue 9, September 2024, bhae375, https://doi.org/10.1093/cercor/bhae375
15. Impact of abl2/arg deficiency on anxiety and depressive behaviors in mice. Xiaojuan Yao, Ruiying Chen, Hongting Chen, Anthony Koleske, Xiao Xiao#, Behavioural Brain Research, (2024), Volume 468, 115022, https://doi.org/10.1016/j.bbr.2024.115022
16. Dorsal dentate gyrus mediated enriched environment-induced anxiolytic and antidepressant effects in cortical infarcted mice. Dan Huang, Yunhui Fan, Jingjun Zhang, Qianfeng Wang, Ming Ding, Ruiqing Hou, Kewei Yu, Xiao Xiao#, Yi Wu#, Junfa Wu#, Experimental Neurology, (2024) Volume 377, 114801, https://doi.org/10.1016/j.expneurol.2024.114801
17. 小鼠二选一赌博实验范式设计及验证。古玥琳，肖晓#，山东大学学报（医学版），（2024）第62卷，第三期
18. High-frequency repetitive transcranial magnetic stimulation promotes ipsilesional functional hyperemia and motor recovery in mice with ischemic stroke. Li Liu*, Ming Ding*, Junfa Wu, Yuwen Zhang, Qianfeng Wang, Nianhong Wang, Lu Luo, Kewei Yu, Yunhui Fan, Jingjun Zhang, Yi Wu#, Xiao Xiao#, Qun Zhang#, Cerebral Cortex (2024), 34 (3), bhae074
19. Integrin α3 Is Required for High-Frequency Repetitive Transcranial Magnetic Stimulation–Induced Glutamatergic Synaptic Transmission in Mice with Ischemia. Li Liu*, Han Hu*, Junfa Wu*, Anthony J. Koleske, Hongting Chen, Nianhong Wang, Kewei Yu, Yi Wu#, Xiao Xiao#, Qun Zhang#, CNS Neuroscience & Therapeutics, (2023), 30 (4), e14498.
20. Deep learning-based activity recognition and fine motor identification with 2D skeleton in cynomolgus monkeys. Chuxi Li*, Zifan Xiao*, Yerong Li, Zhinan Chen, Xun Ji, Yiqun Liu, Shufei Feng, Zhen Zhang, Kaiming Zhang, Jianfeng Feng, Trevor W. Robbins, Shisheng Xiong#, Yongchang Chen, Xiao Xiao#, Zoological Research, (2023) 44(5): 967-980. doi:10.24272/j.issn.2095-8137.2022.449
21. Serpin family proteins as potential biomarkers and therapeutic drugs in stroke: A systematic review and meta-analysis on clinical/preclinical studies. Bing Yan, Lu Luo, Li Liu, Zhenyu Wang, Ruiying Chen, Yi Wu, Xiao Xiao#, CNS Neuroscience & Therapeutics, (2023) 29(7): 1738–1749.
22. Design and evaluation of a rodent-specific focal transcranial magnetic stimulation coil with the custom shielding application in rats. Li Liu, Ming Ding, Junfa Wu, Yuwen Zhang, Shaoqian Guo, Nianhong Wang, Kewei Yu, Lu Luo, Qianfeng Wang, Yuanfeng Weng, Quan Zhang, Kai Qiu, Yi Wu#, Xiao Xiao#, Qun Zhang#, Frontiers in Neuroscience, (2023) DOI: 10.3389/fnins.2023.1129590
23. 广义线性模型在神经电生理信号分析中的应用。 刘子悦; 肖晓#，复旦学报（自然科学版）, (2023), DOI:10.15943/j.cnki.fdxb-jns.20230318.001
24. A tassel-type multilayer flexible neural probe prepared by laser direct writing. Zipeng Ye, Jing Qi, Yiling Ni, Zhiyong Wu,Xiao Xiao#, Shisheng Xiong#, Chip, (2022). 1 (3), 100024. DOI: 10.1016/j.chip.2022.100024 (Cover paper)
25. Corticospinal circuit neuroplasticity may involve silent synapses: implications for functional recovery facilitated by neuromodulation after spinal cord injury. Mingcong Chen, Zuxin Chen, Xiao Xiao, Libing Zhou, Rao Fu, Xian Jiang, Mao Pang, Jianxun Xia#, IBRO Neuroscience Reports (2022). 14, 185-194
26. The role of glia underlying acupuncture analgesia in animal pain models, a systematic review and meta-analysis. Bing Yan, Shengyu Tang, Yuqiu Zhang, Xiao Xiao#, Pain Medicine (2022). , 24 (1), 11-24; doi: 10.1093/pm/pnac115
27. 影响老年人认知健康的街区环境要素——基于2000—2021年国际研究进展。袁琦; 陈泳#;肖晓, 新建筑, 2022, (03): 146-150.
28. Intermittent theta-burst stimulation improves motor function by inhibiting neuronal pyroptosis and regulating microglial polarization via TLR4/NFκB/NLRP3 signaling pathway in cerebral ischemic mice. Lu Luo*, Meixi Liu*, Yunhui Fan, Jingjun Zhang, Li Liu, Yun Li, Qiqi Zhang, Hongyu Xie, Congyu Jiang, Junfa Wu, Xiao Xiao#, Yi Wu#, Journal of Neuroinflammation (2022) 19:141
29. Neurophysiological characteristics in the periventricular/periaqueductal gray correlate with pain perception, sensation, and affect in neuropathic pain patients. Huichun Luo*, Yongzhi Huang*, Alexander L. Green, Tipu Z. Aziz, Xiao Xiao, Shouyan Wang#, NeuroImage: Clinical (2021). 32, 102876
30. MonkeyPosekit: Automated Markerless 2D Pose Estimation of Monkey, Chuxi Li, Chi Yang, Yerong Li, Shufei Feng, Zhen Zhang, Shisheng Xiong#, Xiao Xiao#, IEEE- China Automation Congress (CAC) (2021) 1280-1284
31. 基于时移和片组注意力融合的双流行为识别网络。肖子凡, 刘逸群, 李楚溪, 张力, 王守岩, 肖晓#，计算机系统应用Computer Systems & Applications, (2022) 31(1):204−211
32. The role of the anterior cingulate cortex in translational pain research. Xiao Xiao#, Ming Ding, Yuqiu Zhang#, Neuroscience Bulletin (2021) 37(3), 405-422
33. Distinct function of estrogen receptors in the rodent anterior cingulate cortex in pain-related aversion. Kai-Kai Zang *, Xiao Xiao*,Li-Qiang Chen,Yan Yang, Qi-Lai Cao, Yu-Long Tang, Su-Su Lv, Hong Cao, Ling Zhang, Yu-Qiu Zhang. Anesthesiology (2020) Jul;133(1):165-184
34. Functional dynamics of thalamic local field potentials correlated with modulation of neuropathic pain. Huichun Luo, Yongzhi Huang, Xiao Xiao, Wenjing Dai, Yingnan Nie, Xinyi Geng, Yongzhi Huang, Alex Green, Tipu Aziz, Shouyan Wang#, European Journal of Neuroscience. (2020) 51:628–640
35. Trio haploinsufficiency causes neurodevelopmental disease-associated deficits. Sara M. Katrancha, Amy Zhao, Amanda Jeng, Juliana Shaw, Minsheng Zhu, Christopher Pittenger, Charles Greer, Xiao Xiao#, Anthony J. Koleske# Cell Reports. (2019) 26:2805-2817
36. A new perspective on the anterior cingulate cortex and affective pain. Xiao Xiao, Yuqiu Zhang#. Neuroscience & Biobehavioral Reviews (2018) 90:200-211
37. Noonan syndrome-associated SHP2 dephosphorylates GluN2B to regulate NMDA receptor function. Aaron D. Levy*, Xiao Xiao*, Suma Priya Sudarsana Devi, Anton M. Bennett, Charles A. Greer, James R. Howe, Kazuya Machida, Anthony J. Koleske# Cell Reports (2018) 24 (6):1523-1535
38. CNS neurons deposit Laminin α5 to stabilize synapses. Mitchell H. Omar, Maghan Kerrisk Campbell, Xiao Xiao, Qiaonan Zhong, William J. Brunken, Jeffrey H. Miner, Charles A. Greer, Anthony J. Koleske#, Cell Reports (2017) 21(5): 1281-1292
39. Disruption of coordinated presynaptic and postsynaptic maturation underlies the defects in hippocampal synapse stability and plasticity in Abl2/Arg-deficient mice. Xiao Xiao, Aaron D. Levy, Brian J. Rosenberg, Michael J. Higley, Anthony J. Koleske#, Journal of Neuroscience, (2016) 36 (25): 6778-6791
40. SIP 30 Is Required for Neuropathic Pain-Evoked Aversion in Rats. Mei Han, Xiao Xiao, Yan Yang, Ru-Yi Huang, Hong Cao, Zhi-Qi Zhao, Yu-Qiu Zhang#, Journal of Neuroscience,(2014) 34(2): 346-355
41. Estrogen in the anterior cingulate cortex contributes to pain-related aversion. Xiao Xiao, Yan Zhang, Yan Yang, Zhi-Qi Zhao, Yu-Qiu Zhang#, Cerebral Cortex (2012) 23(9): 2190-2203
42. Estrogen facilitates spinal cord synaptic transmission via mambrane-bound estrogen receptors: implications for pain hypersensitivity. Yan Zhang, Xiao Xiao, Zhi-Qi Zhao, Yu-Qiu Zhang#, Journal of Biological Chemistry,(2012) 287(40):33268-81
43. 综述：一念放下，万般自在——我们能否训练自己去遗忘疼痛. 肖晓, 生理学报Acta Physiologica Sinica, June 25, 2011, 63(3): 293–295
44. NMDA NR2A and NR2B receptors in the rostral anterior cingulate cortex contribute to pain-related aversion in male rats. Ting-Ting Li*, Wen-Hua Ren*, Xiao Xiao*, Long-Zhen Cheng, Xue-Han Zhang, Zhi-Qi Zhao, Yu-Qiu Zhang#. Pain, (2009) 146, 183–193
